Real-time monitoring of tomato plants in plant factories is necessary to identify and classify diseases at the early stages to prevent possible outbreaks. The proposed DeepD381v4plus network exhibits higher class-wise accuracy, sensitivity, specificity, precision, F1 score and Matthews correlation coefficient scores exceeding 0.96 for multi-varietal tomato leaf diseases. During the reproductive stage, bud formation, flower appearance, bite marks and fruit set also need to be monitored to confirm pollination.